Inflammatory profile discriminates clinical subtypes in LRRK2‐associated Parkinson's disease

Background and purpose The presentation of Parkinson's disease patients with mutations in the LRRK 2 gene ( PD LRRK 2 ) is highly variable, suggesting a strong influence of modifying factors. In this context, inflammation is a potential candidate inducing clinical subtypes. Methods An extensive battery of peripheral inflammatory markers was measured in human serum in a multicentre cohort of 142 PD LRRK 2 patients from the MJFF LRRK 2 Consortium,...