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Quantification of brown and white adipose tissue based on Gaussian mixture model using water–fat and T2* MRI in adolescents

Published on Sep 1, 2017in Journal of Magnetic Resonance Imaging3.73
· DOI :10.1002/jmri.25632
Steve C. N. Hui7
Estimated H-index: 7
(CUHK: The Chinese University of Hong Kong),
Jacky Ko2
Estimated H-index: 2
(CUHK: The Chinese University of Hong Kong)
+ 5 AuthorsWinnie C.W. Chu38
Estimated H-index: 38
(CUHK: The Chinese University of Hong Kong)
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  • References (39)
  • Citations (9)
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References39
Newest
K. N. Bhanu Prakash11
Estimated H-index: 11
(Agency for Science, Technology and Research),
H. Srour5
Estimated H-index: 5
(Agency for Science, Technology and Research)
+ 1 AuthorsKai-Hsiang Chuang29
Estimated H-index: 29
(Agency for Science, Technology and Research)
Objective Brown adipose tissue (BAT) plays a key role for thermogenesis in mammals and infants. Recent confirmation of BAT presence in adult humans has aroused great interest for its potential to initiate weight-loss and normalize metabolic disorders in diabetes and obesity. Reliable detection and differentiation of BAT from the surrounding white adipose tissue (WAT) and muscle is critical for assessment/quantification of BAT volume. This study evaluates magnetic resonance (MR) acquisition for B...
Published on Feb 10, 2014in Annual Review of Physiology17.90
Shingo Kajimura40
Estimated H-index: 40
(UCSF: University of California, San Francisco),
Masayuki Saito47
Estimated H-index: 47
(Tenshi College)
Brown adipose tissue (BAT) is specialized to dissipate chemical energy in the form of heat as a defense against cold and excessive feeding. Interest in the field of BAT biology has exploded in the past few years because of the therapeutic potential of BAT to counteract obesity and obesity-related diseases, including insulin resistance. Much progress has been made, particularly in the areas of BAT physiology in adult humans, developmental lineages of brown adipose cell fate, and hormonal control ...
Published on Jan 1, 2014in International Journal of Obesity4.51
A Z Lau1
Estimated H-index: 1
,
A P Chen1
Estimated H-index: 1
+ 3 AuthorsC H Cunningham1
Estimated H-index: 1
Noninvasive identification and assessment of functional brown adipose tissue in rodents using hyperpolarized 13 C imaging
Published on Dec 1, 2013in NMR in Biomedicine3.41
Houchun H. Hu31
Estimated H-index: 31
(Children's Hospital Los Angeles),
Hermien E. Kan22
Estimated H-index: 22
(LUMC: Leiden University Medical Center)
Accurate, precise and reliable techniques for the quantification of body and organ fat distributions are important tools in physiology research. They are critically needed in studies of obesity and diseases involving excess fat accumulation. Proton MR methods address this need by providing an array of relaxometry-based (T1, T2) and chemical shift-based approaches. These techniques can generate informative visualizations of regional and whole-body fat distributions, yield measurements of fat volu...
Published on Oct 30, 2013in PLOS ONE2.78
Jerod Rasmussen14
Estimated H-index: 14
(UCI: University of California, Irvine),
Sonja Entringer34
Estimated H-index: 34
(UCI: University of California, Irvine)
+ 8 AuthorsClaudia Buss37
Estimated H-index: 37
(Charité)
There is a major resurgence of interest in brown adipose tissue (BAT) biology, particularly regarding its determinants and consequences in newborns and infants. Reliable methods for non-invasive BAT measurement in human infants have yet to be demonstrated. The current study first validates methods for quantitative BAT imaging of rodents post mortem followed by BAT excision and re-imaging of excised tissues. Identical methods are then employed in a cohort of in vivo infants to establish the relia...
Published on Oct 1, 2013in Journal of Magnetic Resonance Imaging3.73
Houchun H. Hu31
Estimated H-index: 31
(Children's Hospital Los Angeles),
Larry Yin7
Estimated H-index: 7
(Children's Hospital Los Angeles)
+ 3 AuthorsVicente Gilsanz52
Estimated H-index: 52
(Children's Hospital Los Angeles)
Purpose To compare fat-signal fractions (FFs) and T2* values between brown (BAT) and white (WAT) adipose tissue located within the supraclavicular fossa and subcutaneous depots, respectively. Materials and Methods Twelve infants and 39 children were studied. Children were divided into lean and overweight/obese subgroups. Chemical-shift-encoded water-fat magnetic resonance imaging (MRI) was used to quantify FFs and T2* metrics in the supraclavicular and adjacent subcutaneous adipose tissue depots...
Published on Oct 1, 2013in Nature Medicine30.64
Matthew Harms7
Estimated H-index: 7
,
Patrick Seale42
Estimated H-index: 42
There is much interest in brown and beige adipocytes, as their thermogenic activities can suppress weight gain and metabolic disease in rodent models. The authors review recent data that have provided new insights into the development and biology of brown and beige adipocytes and critically assess the possibilities for manipulating these cells to combat obesity and its associated diseases.
Published on Sep 10, 2013in PLOS ONE2.78
Rosa T. Branca16
Estimated H-index: 16
(UNC: University of North Carolina at Chapel Hill),
Le Zhang3
Estimated H-index: 3
(UNC: University of North Carolina at Chapel Hill)
+ 5 AuthorsRobert R. Maronpot61
Estimated H-index: 61
The recent discovery of active Brown Adipose Tissue (BAT) in adult humans has opened new avenues for obesity research and treatment, as reduced BAT activity seem to be implicated in human energy imbalance, diabetes, and hypertension. However, clinical applications are currently limited by the lack of non-invasive tools for measuring mass and function of this tissue in humans. Here we present a new magnetic resonance imaging method based on the normally invisible intermolecular multiple-quantum c...
Published on Sep 1, 2013in The Journal of Nuclear Medicine7.35
Y. Iris Chen26
Estimated H-index: 26
(Harvard University),
Aaron M. Cypess29
Estimated H-index: 29
(Harvard University)
+ 4 AuthorsKenneth K. Kwong64
Estimated H-index: 64
(Harvard University)
Brown adipose tissue (BAT) is a unique organ whose role is to consume fat calories by generating heat in response to cold exposure (1–4). BAT energy expenditure may also be used to counterbalance the accumulation of stored energy in white adipose tissue (WAT), making induction of BAT thermogenesis a promising target for treating obesity and metabolic disease. Unfortunately, these goals cannot be met until BAT volume and activity in humans can be quantified, which has been a challenge since the o...
Cited By9
Newest
Published on Jan 25, 2019in Journal of Magnetic Resonance Imaging3.73
Daniela Franz5
Estimated H-index: 5
(TUM: Technische Universität München),
Maximilian N. Diefenbach4
Estimated H-index: 4
(TUM: Technische Universität München)
+ 11 AuthorsThomas Baum25
Estimated H-index: 25
(TUM: Technische Universität München)
Published on May 1, 2019in European Journal of Clinical Nutrition3.11
Takashi Abe21
Estimated H-index: 21
(University of Mississippi),
Jeremy P. Loenneke33
Estimated H-index: 33
(University of Mississippi)
+ 2 AuthorsTakuya Akamine2
Estimated H-index: 2
(National Institute of Fitness and Sports in Kanoya)
To investigate the impact of eliminating fat-free adipose tissue (aFFAT) on the prevalence of low muscle mass in older adults. Three hundred and forty-three (153 men and 190 women) well-functioning Japanese older adults (aged 65–79) had their appendicular lean mass (aLM) and appendicular fat mass (aFM) measured using dual-energy X-ray absorptiometry (DXA). aFFAT was then estimated from DXA-derived aFM (aFM = (FM/0.15)*0.85). Both traditional cutoffs and those corrected for aFFAT were used for di...
Published on Feb 1, 2019in European Radiology3.96
Steve C. N. Hui7
Estimated H-index: 7
(CUHK: The Chinese University of Hong Kong),
Simon K. Wong22
Estimated H-index: 22
(CUHK: The Chinese University of Hong Kong)
+ 3 AuthorsWinnie C.W. Chu38
Estimated H-index: 38
(CUHK: The Chinese University of Hong Kong)
Objectives To study the change in brown and white adipose tissue (BAT and WAT), as well as fat content in the liver and pancreas, in patients with morbid obesity before and after bariatric surgery.
Published on Jan 1, 2019in Sports Medicine7.58
Takashi Abe21
Estimated H-index: 21
(University of Mississippi),
Jeremy P. Loenneke33
Estimated H-index: 33
(University of Mississippi),
Robert S. Thiebaud23
Estimated H-index: 23
(Texas Wesleyan University)
Fat-free body mass (FFM) is a surrogate for skeletal muscle mass and is often used for the normalization of several physiological variables (e.g., oxygen uptake). However, FFM includes non-skeletal muscle components such as the fat-free component of adipose tissue fat cells. As the amount of adipose tissue mass increases, the FFM will also increase and be included in the measurement of FFM. Therefore, FFM may not be an appropriate indicator of muscle mass when targeting individuals with a large ...
Published on Dec 1, 2018in Journal of Clinical Densitometry2.18
Takashi Abe21
Estimated H-index: 21
(University of Mississippi),
Zachary W. Bell3
Estimated H-index: 3
(University of Mississippi)
+ 3 AuthorsJeremy P. Loenneke33
Estimated H-index: 33
(University of Mississippi)
Abstract Fat-free mass as well as lean soft tissue mass is a surrogate for skeletal muscle mass and is often used for the normalization of several physiological variables or for the diagnosing of low muscle mass in older adults. However, both fat-free mass and lean tissue mass include nonskeletal muscle components such as the fat-free component of adipose tissue fat cells. A technique known as water-fat MRI provides a noninvasive and radiation-free assessment of the fat-free component of adipose...
Published on Apr 1, 2018in Journal of Magnetic Resonance Imaging3.73
Jie Deng42
Estimated H-index: 42
(NU: Northwestern University),
Lisa M. Neff9
Estimated H-index: 9
(NU: Northwestern University)
+ 5 AuthorsLewis Landsberg55
Estimated H-index: 55
(NU: Northwestern University)
Purpose To implement quantitative Dixon magnetic resonance imaging (MRI) methods for brown adipose tissue (BAT) characterization at inactive and cold-activated states in normal weight, overweight, and obese subjects. The hypotheses are that MRI characteristics of BAT would differentiate between nonobese and obese subjects, and activation of BAT in response to thermal challenges that are detected by MRI would be correlated with BAT activity measured by positron emission tomography / computed tomo...
Published on Jan 1, 2018
Dimitrios C. Karampinos24
Estimated H-index: 24
(TUM: Technische Universität München),
Dominik Weidlich3
Estimated H-index: 3
(TUM: Technische Universität München)
+ 2 AuthorsDaniela Franz5
Estimated H-index: 5
(TUM: Technische Universität München)
The present review reports on the current knowledge and recent findings in magnetic resonance imaging (MRI) and spectroscopy (MRS) of brown adipose tissue (BAT). The work summarizes the features and mechanisms that allow MRI to differentiate BAT from white adipose tissue (WAT) by making use of their distinct morphological appearance and the functional characteristics of BAT. MR is a versatile imaging modality with multiple contrast mechanisms as potential candidates in the study of BAT, targetin...