Knockout of the primary sclerosing cholangitis‐risk gene Fut2 causes liver disease in mice

The etiopathogenesis of primary sclerosing cholangitis is unknown. Genetic variants of fucosyltransferase 2 (FUT2) have been identified in genome‐wide association studies as risk factors for primary sclerosing cholangitis. We investigated the role of Fut2 in murine liver pathophysiology by studying Fut2–/– mice. Fut2–/– mice were viable and fertile, had lower body weight than wild‐type (wt) littermates and gray fur. Half of the Fut2–/– mice...