Zebrafish phenotypic screen identifies novel Notch antagonists

Volume: 35, Issue: 2, Pages: 166 - 179
Published: Jan 5, 2017
Abstract
Zebrafish represents a powerful in vivo model for phenotype-based drug discovery to identify clinically relevant small molecules. By utilizing this model, we evaluated natural product derived compounds that could potentially modulate Notch signaling that is important in both zebrafish embryogenesis and pathogenic in human cancers. A total of 234 compounds were screened using zebrafish embryos and 3 were identified to be conferring phenotypic...
Paper Details
Title
Zebrafish phenotypic screen identifies novel Notch antagonists
Published Date
Jan 5, 2017
Volume
35
Issue
2
Pages
166 - 179
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