Expanding the genetic code in vertebrates
Abstract
Synthetic Biology
Unnatural amino acids can be incorporated into target proteins by using a transfer RNA (tRNA)—aminoacyl-tRNA synthetase pair that adds an unnatural amino acid at an amber stop codon. The strategy has been used in prokaryotic and eukaryotic cells and for generating transgenic invertebrates. Chen et al. have succeeded in integrating a construct coding for the unnatural amino acid p -azido-phenylalanine (AzF) into the mouse...
Paper Details
Title
Expanding the genetic code in vertebrates
Published Date
Jan 5, 2017
Journal
Volume
355
Issue
6320
Pages
36.3 - 36
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Notes
History