The STIM-Orai coupling interface and gating of the Orai1 channel
Abstract
In virtually all cells, store-operated Ca2+ entry signals are vital in controlling a spectrum of functions. The signals are mediated by STIM proteins in the ER and Orai channels in the PM which undergo a dynamic coupling process within discrete ER-PM junctional regions. This coupling is initiated by depletion of ER stored Ca2+ triggering STIM proteins to undergo an intricate activation process. Thereafter, STIM proteins become trapped in the...
Paper Details
Title
The STIM-Orai coupling interface and gating of the Orai1 channel
Published Date
May 1, 2017
Journal
Volume
63
Pages
8 - 13
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