Mulberry and its main components protect against oxidized low-density lipoprotein-induced endothelial nitric oxide synthase uncoupling

Nitric oxide (NO), which is produced by endothelial NO synthase (eNOS), is an important protective molecule in the vasculature. However, eNOS coupling and its resultant activation are altered under oxidative stress. Under these conditions, eNOS uses molecular oxygen as a substrate instead of l-arginine, resulting in the production of superoxide anion radicals (O2-) rather than NO. We explored the effects of mulberry extract and its components on...