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Construction of longitudinal prediction targets using semisupervised learning

Published on Sep 1, 2018in Statistical Methods in Medical Research2.388
· DOI :10.1177/0962280216684163
Booil Jo33
Estimated H-index: 33
(Stanford University),
Robert L. Findling72
Estimated H-index: 72
(Johns Hopkins University)
+ 8 AuthorsSarah McCue Horwitz30
Estimated H-index: 30
(NYU: New York University)
Abstract
In establishing prognostic models, often aided by machine learning methods, much effort is concentrated in identifying good predictors. However, the same level of rigor is often absent in improving...
  • References (25)
  • Citations (3)
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References25
Newest
A limiting feature of previous work on growth mixture modeling is the assumption of normally distributed variables within each latent class. With strongly non-normal outcomes, this means that several latent classes are required to capture the observed variable distributions. Being able to relax the assumption of within-class normality has the advantage that a non-normal observed distribution does not necessitate using more than one class to fit the distribution. It is valuable to add parameters ...
40 CitationsSource
#1Chen Pin Wang (University of Texas Health Science Center at San Antonio)H-Index: 18
#2Booil Jo (Stanford University)H-Index: 33
Last. C. Hendricks Brown (NU: Northwestern University)H-Index: 49
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We propose a principal stratification approach to assess causal effects in nonrandomized longitudinal comparative effectiveness studies with a binary endpoint outcome and repeated measures of a continuous intermediate variable. Our method is an extension of the principal stratification approach originally proposed for the longitudinal randomized study “Prevention of Suicide in Primary Care Elderly: Collaborative Trial” to assess the treatment effect on the continuous Hamilton depression score ad...
8 CitationsSource
#1Robert L. Findling (Johns Hopkins University)H-Index: 72
#2Booil Jo (Stanford University)H-Index: 33
Last. Sarah McCue Horwitz (NYU: New York University)H-Index: 30
view all 18 authors...
Youth receiving mental health services often experience numerous mania-like symptoms (1, 2). Furthermore, although symptoms of mania are, by definition, present in youth suffering from bipolar disorder, prior data have noted that many youth who experience manic symptomatology do not suffer from bipolar disorder (3-7). Whether or not a youth has suffered from a bipolar disorder, it has been noted that elevated symptoms of mania (ESM) are associated with substantial psychosocial impairments and no...
29 CitationsSource
#1Gareth M. JamesH-Index: 25
#2Daniela WittenH-Index: 34
Last. Robert TibshiraniH-Index: 128
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1,967 CitationsSource
#1Ralitza Gueorguieva (Yale University)H-Index: 45
#2Craig MallinckrodtH-Index: 1
Last. John H. KrystalH-Index: 116
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Context: The high percentage of failed clinical trials in depression may be due to high placebo response rates and the failure of standard statistical approaches to capture heterogeneity in treatment response. Objective: To assess whether growth mixture modeling can provide insights into antidepressant and placebo responses in clinical trials of patients with major depression. Design: We reanalyzed clinical trials of duloxetine to identify distinct trajectories of Hamilton Scale for Depression (...
73 CitationsSource
#1Laura B. Dunn (UCSF: University of California, San Francisco)H-Index: 38
#2Bruce A. Cooper (UCSF: University of California, San Francisco)H-Index: 51
Last. Christine Miaskowski (UCSF: University of California, San Francisco)H-Index: 72
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Objective Most longitudinal studies of depressive symptoms reported mean symptom scores that tend to obscure interindividual heterogeneity in the symptom experience. The identification of subgroups of patients with distinct trajectories of depressive symptoms may help identify high risk individuals who require an intervention. This study aimed to identify subgroups of breast cancer patients (n=398) with distinct trajectories of depressive symptoms in the first six months after surgery, as well a...
79 CitationsSource
#1Robert L. Findling (Case Western Reserve University)H-Index: 72
#2Eric A. Youngstrom (UNC: University of North Carolina at Chapel Hill)H-Index: 60
Last. Sarah McCue Horwitz (Stanford University)H-Index: 23
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Objective To examine differences in psychiatric symptomatology, diagnoses, demographics, functioning, and psychotropic medication exposure in children with elevated symptoms of mania (ESM+) compared to youth without ESM (ESM−).
84 CitationsSource
#1Sarah McCue Horwitz (Stanford University)H-Index: 23
#2Christine A. Demeter (Case Western Reserve University)H-Index: 23
Last. Robert L. Findling (Case Western Reserve University)H-Index: 72
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Objective—To describe the design of a longitudinal study of youth with elevated symptoms of mania (ESM) as well as the prevalence and correlates of manic symptoms. Bipolar disorder in youth is serious and is surrounded by controversy about its phenomenology, course and treatment. Yet, there are no longitudinal studies of youth selected only for ESM, the phenomenological hallmark. The study’s objective is to document the rate and sociodemographic correlates of ESM in children attending outpatient...
59 CitationsSource
#1Niklaus Stulz (UPenn: University of Pennsylvania)H-Index: 14
#2Michael E. Thase (UPenn: University of Pennsylvania)H-Index: 113
Last. Paul Crits-Christoph (UPenn: University of Pennsylvania)H-Index: 60
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Objective: Psychotherapy–pharmacotherapy combinations are frequently recommended for the treatment of chronic depressive disorders. Our aim in this novel reanalysis of archival data was to identify patient subgroups on the basis of symptom trajectories and examine the clinical significance of the resultant classification on basis of differential treatment effects to psychotherapy (cognitive behavioral analysis system of psychotherapy), pharmacotherapy (nefazodone), and their combination. Method:...
29 CitationsSource
#1Hanno Petras (UMD: University of Maryland, College Park)H-Index: 20
#2Katherine E. Masyn (UC Davis: University of California, Davis)H-Index: 25
Many studies of youth, adolescents, and adults related to delinquent, antisocial, and criminal offending, have utilized a language of trajectory typologies to describe individual differences in the behavioral course manifest in their longitudinal data. The two most common statistical methods currently in use are the semiparametric group-based modeling, also known as latent class growth analysis and general growth mixture analysis, with the latter method being the focus of this chapter. In concer...
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#1Eric A. Youngstrom (UNC: University of North Carolina at Chapel Hill)H-Index: 60
#2Anna Van MeterH-Index: 9
Last. Robert L. Findling (Johns Hopkins University)H-Index: 72
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To develop short forms of parent-rated mania and depression scales, evaluating their reliability, content coverage, criterion validity, and diagnostic accuracy. Caregivers completed the Parent Gene...
4 CitationsSource
#1William E. Pelham (ASU: Arizona State University)H-Index: 92
#2Hanno Petras (AIR: American Institutes for Research)H-Index: 20
Last. Dustin A. Pardini (ASU: Arizona State University)H-Index: 46
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The cost-effectiveness of targeted delinquency prevention programs for children depends on the accuracy of the screening process. Screening accuracy is often poor, resulting in wasted resources and missed opportunities to avert negative outcomes. This study examined whether screening approaches based on logistic regression or machine learning algorithms could improve accuracy relative to traditional sum-score approaches when identifying boys in the 5th grade (N = 1012) who would be repeatedly ar...
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#1Sheng-Qiang Chi (ZJU: Zhejiang University)H-Index: 2
#2Xinhang Li (Columbia University)
Last. Jingsong Li (ZJU: Zhejiang University)H-Index: 2
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Abstract The utility of a prediction model depends on its generalizability to patients drawn from different but related populations. We explored whether a semi-supervised learning model could improve the generalizability of colorectal cancer (CRC) risk prediction relative to supervised learning methods. Data on 113,141 patients diagnosed with nonmetastatic CRC from 2004 to 2012 were obtained from the Surveillance Epidemiology End Results registry for model development, and data on 1149 patients ...
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#1Boris Birmaher (University of Pittsburgh)H-Index: 93
#2John Merranko (University of Pittsburgh)H-Index: 7
Last. Martin B. Keller (Brown University)H-Index: 118
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Objective Youth with subthreshold mania are at increased risk of conversion to bipolar disorder (BP) I/II. Predictors for conversion have been published for the group as a whole. However, risk factors are heterogeneous, indicating the need for personalized risk assessment. Method One hundred forty youth with BP not otherwise specified (BP-NOS; 6–17 years old) followed through the Course and Outcome of Bipolar Youth (COBY) study with at least 1 follow-up assessment before conversion to BP-I/II we...
5 CitationsSource