Abstract 461: Inhibition of Four- and- a- Half LIM Domain Protein-2 Decreases Atherosclerosis in Apoe -/- Mice model: Role of Immune T- Cells

OBJECTIVE Four-and-a-half LIM domain protein-2 (FHL2), a member of the FHL family of proteins, is expressed in endothelial and vascular smooth muscle cells. FHL2 negatively regulates endothelial cell survival and migration, but its role in atherogenesis is unknown. METHODS AND RESULTS To investigate the role of FHL2 in atherosclerosis, we crossed FHL2 knockout (FHL2-/-) with apolipoprotein (Apo) E-deficient (ApoE -/-) mice, and fed them a high...