Induction of necroptotic cell death by viral activation of the RIG-I or STING pathway
Abstract
Necroptosis is a form of necrotic cell death that requires the activity of the death domain-containing kinase RIP1 and its family member RIP3. Necroptosis occurs when RIP1 is deubiquitinated to form a complex with RIP3 in cells deficient in the death receptor adapter molecule FADD or caspase-8. Necroptosis may play a role in host defense during viral infection as viruses like vaccinia can induce necroptosis while murine cytomegalovirus encodes a...
Paper Details
Title
Induction of necroptotic cell death by viral activation of the RIG-I or STING pathway
Published Date
Jan 6, 2017
Journal
Volume
24
Issue
4
Pages
615 - 625
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