RNA Exosome and Non-coding RNA-Coupled Mechanisms in AID-Mediated Genomic Alterations
Abstract
The eukaryotic RNA exosome is a well-conserved protein complex with ribonuclease activity implicated in RNA metabolism. Various families of non-coding RNAs have been identified as substrates of the complex, underscoring its role as a non-coding RNA processing/degradation unit. However, the role of RNA exosome and its RNA processing activity on DNA mutagenesis/alteration events have not been investigated until recently. B lymphocytes use two DNA...
Paper Details
Title
RNA Exosome and Non-coding RNA-Coupled Mechanisms in AID-Mediated Genomic Alterations
Published Date
Oct 1, 2017
Journal
Volume
429
Issue
21
Pages
3230 - 3241
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