Muscle-specific deletion of BDK amplifies loss of myofibrillar protein during protein undernutrition
Abstract
Branched-chain amino acids (BCAAs) are essential amino acids for mammals and play key roles in the regulation of protein metabolism. However, the effect of BCAA deficiency on protein metabolism in skeletal muscle in vivo remains unclear. Here we generated mice with lower BCAA concentrations by specifically accelerating BCAA catabolism in skeletal muscle and heart (BDK-mKO mice). The mice appeared to be healthy without any obvious defects when...
Paper Details
Title
Muscle-specific deletion of BDK amplifies loss of myofibrillar protein during protein undernutrition
Published Date
Jan 4, 2017
Journal
Volume
7
Issue
1
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