Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome
Abstract
Like all retroviruses, HIV-1 irreversibly inserts a viral DNA (vDNA) copy of its RNA genome into host target DNA (tDNA). The intasome, a higher-order nucleoprotein complex composed of viral integrase (IN) and the ends of linear vDNA, mediates integration. Productive integration into host chromatin results in the formation of the strand transfer complex (STC) containing catalytically joined vDNA and tDNA. HIV-1 intasomes have been refractory to...
Paper Details
Title
Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome
Published Date
Jan 6, 2017
Journal
Volume
355
Issue
6320
Pages
89 - 92
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