Smoking activates cytotoxic CD8+ T cells and causes survivin release in rheumatoid arthritis
Abstract
CD8+ T cells have an emerging role in RA. Resent research indicates a causal relationship between the non-exhausted state of CD8+ T cells, defined by lost function of PD-1, and development of arthritis. We investigated how smoking contributes to the non-exhausted phenotype of CD8+ T cells and cause survivin release to serum. We compared serum survivin levels between smokers and non-smokers in 252 RA and 168 healthy subjects. Nicotine effects on...
Paper Details
Title
Smoking activates cytotoxic CD8+ T cells and causes survivin release in rheumatoid arthritis
Published Date
Mar 1, 2017
Journal
Volume
78
Pages
101 - 110
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Notes
History