Coronary artery disease and proprotein convertase subtilisin/kexin 9: A new platelet activator

Introduction: Proprotein convertase subtilisin/kexin 9 (PCSK9) plays a role in low-density lipoprotein cholesterol (LDLC) homeostasis, increasing hepatic degradation of LDL receptor (LDLR), thus leading to an increase in LDLC levels. Levels of PCSK9 predict recurrent cardiovascular events in patients with stable angina (SA) even in those with well-controlled LDL-C level. Experimental studies have suggested that PCSK9 contribution to...