Basal Ganglia Dysfunction Contributes to Physical Inactivity in Obesity
Abstract
Obesity is associated with physical inactivity, which exacerbates the health consequences of weight gain. However, the mechanisms that mediate this association are unknown. We hypothesized that deficits in dopamine signaling contribute to physical inactivity in obesity. To investigate this, we quantified multiple aspects of dopamine signaling in lean and obese mice. We found that D2-type receptor (D2R) binding in the striatum, but not D1-type...
Paper Details
Title
Basal Ganglia Dysfunction Contributes to Physical Inactivity in Obesity
Published Date
Feb 1, 2017
Journal
Volume
25
Issue
2
Pages
312 - 321
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History