Abstract 4859: Development of a cancer transcriptome analysis toolkit: identification of gene fusions in chronic lymphocytic leukemia

RNA-Seq has become an invaluable tool for improving the understanding of the biological mechanisms at work in various cancers, with tantalizing prospects for application in the area of clinical diagnostics and for the design and monitoring of therapy. Transcriptome data uniquely provides information on gene expression, and the presence of somatic expressed splice variants, point mutations, CNVs and gene fusions. Although diverse algorithms have...