Association Between Loss-of-Function Mutations Within the FANCM Gene and Early-Onset Familial Breast Cancer
Abstract
Germline mutations in established moderately or highly penetrant risk genes for breast cancer (BC) and/or ovarian cancer (OC), including BRCA1 and BRCA2, explain fewer than half of all familial BC and/or OC cases. Based on the genotyping of 2 loss-of-function (LoF) variants c.5101C>T (p.GIn1701Ter [rs147021911]) and c.5791C>T (p.Arg1931Ter [rs144567652]), the FANCM gene has been suggested as a novel BC predisposition gene, while the analysis of...
Paper Details
Title
Association Between Loss-of-Function Mutations Within the FANCM Gene and Early-Onset Familial Breast Cancer
Published Date
Sep 1, 2017
Journal
Volume
3
Issue
9
Pages
1245 - 1245
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