Local Genetic Correlation Gives Insights into the Shared Genetic Architecture of Complex Traits

Volume: 101, Issue: 5, Pages: 737 - 751
Published: Nov 2, 2017
Abstract
Although genetic correlations between complex traits provide valuable insights into epidemiological and etiological studies, a precise quantification of which genomic regions disproportionately contribute to the genome-wide correlation is currently lacking. Here, we introduce ρ-HESS, a technique to quantify the correlation between pairs of traits due to genetic variation at a small region in the genome. Our approach requires GWAS summary data...
Paper Details
Title
Local Genetic Correlation Gives Insights into the Shared Genetic Architecture of Complex Traits
Published Date
Nov 2, 2017
Volume
101
Issue
5
Pages
737 - 751
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