Synchrotron X-Ray Fluorescence Nanoprobe Reveals Target Sites for Organo-Osmium Complex in Human Ovarian Cancer Cells

A variety of transition metal complexes exhibit anticancer activity, but their target sites in cells need to be identified and mechanisms of action elucidated. Here, it was found that the sub‐cellular distribution of [Os(η 6 ‐ p ‐cym)(Azpy‐NMe 2 )I] + ( p ‐cym= p ‐cymene, Azpy‐NMe 2 =2‐( p ‐[dimethylamino]phenylazo)pyridine) ( 1 ), a promising drug candidate, can be mapped in human ovarian cancer cells at pharmacological concentrations using a...