Abstract 2272: A novel epigenetic regulator histone demethylase NO66 promotes prostate cancer bone metastasis
Abstract
Epigenetic changes by histone methylation that affect expression of key genes linked to progression and metastasis of androgen-independent prostate cancer (PCa) cells remain elusive. Histone demethylase NO66 is a JumonjiC-domain containing histone demethylase specific for H3K4me3 and H3K36me3 and acts as an inhibitor of bone formation. NO66 interacts with EZH2 (enhancer of zeste homolog 2) containing PRC2 (polycomb-repressor complex 2), which...
Paper Details
Title
Abstract 2272: A novel epigenetic regulator histone demethylase NO66 promotes prostate cancer bone metastasis
Published Date
Aug 1, 2015
Journal
Volume
75
Issue
15_Supplement
Pages
2272 - 2272
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