Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells
Abstract
MicroRNAs (miRNAs) loss-of-function phenotypes are mainly induced by chemically modified antisense oligonucleotides. Here we develop an alternative inhibitor for miRNAs, termed ‘small RNA zipper’. It is designed to connect miRNA molecules end to end, forming a DNA–RNA duplex through a complementary interaction with high affinity, high specificity and high stability. Two miRNAs, miR-221 and miR-17, are tested in human breast cancer cell lines,...
Paper Details
Title
Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells
Published Date
Jan 3, 2017
Journal
Volume
8
Issue
1
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