Tofacitinib relieves symptoms of stimulator of interferon genes (STING)–associated vasculopathy with onset in infancy caused by 2 de novo variants in TMEM173
Volume: 139, Issue: 4, Pages: 1396 - 1399.e12
Published: Apr 1, 2017
Abstract
Stimulator of interferon genes (STING), which is encoded by transmembrane protein 173 (TMEM173), is an important mediator in initiating innate immune responses by detecting aberrant DNA species or cyclic di-GMP-AMP (cGAMP) in the cytosol and driving synthesis of type I interferon.1Barber G.N. STING: infection, inflammation and cancer.Nat Rev Immunol. 2015; 15: 760-770Crossref PubMed Scopus (682) Google Scholar, 2Jeremiah N. Neven B. Gentili M....
Paper Details
Title
Tofacitinib relieves symptoms of stimulator of interferon genes (STING)–associated vasculopathy with onset in infancy caused by 2 de novo variants in TMEM173
Published Date
Apr 1, 2017
Volume
139
Issue
4
Pages
1396 - 1399.e12
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