357. Blood-Brain Interface Opening By Ultrasound in Adult Common Marmoset To Induce Brain Pathology With rAAV

Background: The common marmoset (Callithrix jacchus) could provide an appropriate model for neuromuscular diseases because of its higher brain function and physiological resemblance to human. Although production of transgenic marmosets from zygote transduced with lentiviral vector were reported, this strategy is too costly and not efficient with various reasons. In contrast, an adeno-associated virus vector (rAAV) has great advantages to induce...