Inhibition of CRISPR-Cas9 with Bacteriophage Proteins
Abstract
Bacterial CRISPR-Cas systems utilize sequence-specific RNA-guided nucleases to defend against bacteriophage infection. As a countermeasure, numerous phages are known that produce proteins to block the function of class 1 CRISPR-Cas systems. However, currently no proteins are known to inhibit the widely used class 2 CRISPR-Cas9 system. To find these inhibitors, we searched cas9-containing bacterial genomes for the co-existence of a CRISPR spacer...
Paper Details
Title
Inhibition of CRISPR-Cas9 with Bacteriophage Proteins
Published Date
Jan 1, 2017
Journal
Volume
168
Issue
1-2
Pages
150 - 158.e10
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