Effects of Crataegus pentagyna on cardiomyocytes (CMs) differentiated from CPVT1 patient-derived induced pluripotent stem cells (iPSCs)

Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. The discovery of induced pluripotent stem cells (iPSCs) was a milestone providing a great opportunity for modeling hereditary cardiac arrhythmias as well as developing new drugs or testing their toxicity [1, 2]. Human iPSC models have been described for the cardiac arrhythmia syndromes including LQTS and Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT). CPVT...