Meta-analysis of quantitative pleiotropic traits for next-generation sequencing with multivariate functional linear models
Abstract
To analyze next-generation sequencing data, multivariate functional linear models are developed for a meta-analysis of multiple studies to connect genetic variant data to multiple quantitative traits adjusting for covariates. The goal is to take the advantage of both meta-analysis and pleiotropic analysis in order to improve power and to carry out a unified association analysis of multiple studies and multiple traits of complex disorders. Three...
Paper Details
Title
Meta-analysis of quantitative pleiotropic traits for next-generation sequencing with multivariate functional linear models
Published Date
Dec 21, 2016
Volume
25
Issue
3
Pages
350 - 359
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