Effect of Terpene on Physicochemical Properties and Skin Permeability of Capsaicin Loaded Solid Lipid Nanoparticles

Introduction: Capsaicin (CAP) is the major active compound of chili piper. Previous study has been reported that CAP was used orally or topically for pain relief by rheumatism, neuralgia, lumbago or sciatica. However, the significant first pass metabolism, the short half-life and the poor water solubility of CAP lead to its limitation in the development of CAP formulations as novel pharmaceutical products. The objective of this study was to...