Original paper
Generation of Hoxc13 knockout pigs recapitulates human ectodermal dysplasia–9
Abstract
Atrichia and sparse hair phenotype cause distress to many patients. Ectodermal dysplasia-9 (ED-9) is a congenital condition characterized by hypotrichosis and nail dystrophy without other disorders, and Hoxc13 is a pathogenic gene for ED-9. However, mice carrying Hoxc13 mutation present several other serious disorders, such as skeletal defects, progressive weight loss and low viability. Mouse models cannot faithfully mimic human ED-9. In this...
Paper Details
Title
Generation of Hoxc13 knockout pigs recapitulates human ectodermal dysplasia–9
Published Date
Dec 22, 2016
Journal
Pages
ddw378 - ddw378
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Notes
History