264. Absence of CD8 T Cell Responses Against AAV Capsid Using Reduced Vector Dose or Library Selected Liver Targeted AAV2 Based Capsids

Predicting immune responses directed against the AAV capsid have proven to be a challenge in the translation of liver directed AAV gene therapy into the clinic. Previously we have described the first mouse model that allows us to evaluate the potential for CD8 T cell responses directed against AAV transduced hepatocytes and to define protocols and conditions to minimize this response (Martino et al. Blood 2013). Empirical data from both AAV2 and...