Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks
Abstract
Human cancers are characterized by the presence of oncogene-induced DNA replication stress (DRS), making them dependent on repair pathways such as break-induced replication (BIR) for damaged DNA replication forks. To better understand BIR, we performed a targeted siRNA screen for genes whose depletion inhibited G1 to S phase progression when oncogenic cyclin E was overexpressed. RAD52, a gene dispensable for normal development in mice, was among...
Paper Details
Title
Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks
Published Date
Dec 1, 2016
Journal
Volume
64
Issue
6
Pages
1127 - 1134
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