Abstract A15: Immunohistochemical patterns of the breast developmental gene, ELF5, reveals differential expression in high grade hormone receptor negative clinical breast cancer

ELF5 is a master regulator of breast lobular development, is enriched in luminal progenitor cells and has been implicated in breast carcinogenesis and may be a chemopreventive biomarker and target. In our laboratory, mammary cancer prone mice treated with the chemopreventive and anti-estrogen tamoxifen have fewer mammary hyperplastic lobules, reduced ELF5 mRNA expression and reduced tumor incidence. ELF5 mRNA is also expressed in multiple breast...