Abstract 2932: Role of death receptor 5 (DR5) in apoptosis induced by anticancer agents in colon cancer cells

The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor, also called death receptor 5 (DR5; TRAIL receptor2), is a member of the death receptor family that shares a cysteine-rich extracellular domain and a cytoplasmic death domain. DR5 is located on cell surface, becomes activated upon binding to its ligand TRAIL or overexpression, and then signals apoptosis initiation through an FADD/caspase 8-dependant caspase activation...