Non-linear impact of glutathione depletion on C. elegans life span and stress resistance
Abstract
The redox environment in cells and organisms is set by low-molecular mass and protein-bound thiols, with glutathione (GSH) representing a major intracellular redox buffer. Subtle thiol oxidation elicits signal transduction processes and adaptive responses to cope with stressors, whereas highly oxidizing conditions may provoke cell death. We here tested how thiol depletion affects life span, stress resistance and stress signaling in the model...
Paper Details
Title
Non-linear impact of glutathione depletion on C. elegans life span and stress resistance
Published Date
Apr 1, 2017
Journal
Volume
11
Pages
502 - 515
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