MicroRNAs as novel elements in personalized radiotherapy

Radiotherapy (RT) is a widely used and effective non-surgical cancer treatment. However, the mechanism behind several major challenges to efficacy, such as tumor radioresistance, normal tissue toxicity, individual radiation hypersensitivity and promoted metastatic spread, are not fully understood. The involvement of microRNAs (miRNAs) in processes important for tissue radiation responses, including DNA damage repair, activation of signalling...