Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium tuberculosis Proteasome
Abstract
The 20S core particle of the proteasome in Mycobacterium tuberculosis (Mtb) is a promising, yet unconventional, drug target. This multimeric peptidase is not essential, yet degrades proteins that have become damaged and toxic via reactions with nitric oxide (and/or the associated reactive nitrogen intermediates) produced during the host immune response. Proteasome inhibitors could render Mtb susceptible to the immune system, but they would only...
Paper Details
Title
Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium tuberculosis Proteasome
Published Date
Dec 5, 2016
Journal
Volume
3
Issue
2
Pages
176 - 181
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