novoBreak: local assembly for breakpoint detection in cancer genomes

The novoBreak software provides sensitive, accurate, and comprehensive detection of structural variation in somatic next-generation sequencing data. We present novoBreak, a genome-wide local assembly algorithm that discovers somatic and germline structural variation breakpoints in whole-genome sequencing data. novoBreak consistently outperformed existing algorithms on real cancer genome data and on synthetic tumors in the ICGC-TCGA DREAM 8.5...