Human mitochondrial transcription factors TFAM and TFB2M work synergistically in promoter melting during transcription initiation.

Volume: 45, Issue: 2, Pages: 861 - 874
Published: Jan 25, 2017
Abstract
Human mitochondrial DNA is transcribed by POLRMT with the help of two initiation factors, TFAM and TFB2M. The current model postulates that the role of TFAM is to recruit POLRMT and TFB2M to melt the promoter. However, we show that TFAM has 'post-recruitment' roles in promoter melting and RNA synthesis, which were revealed by studying the pre-initiation steps of promoter binding, bending and melting, and abortive RNA synthesis. Our 2-aminopurine...
Paper Details
Title
Human mitochondrial transcription factors TFAM and TFB2M work synergistically in promoter melting during transcription initiation.
Published Date
Jan 25, 2017
Volume
45
Issue
2
Pages
861 - 874
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