Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations

Analysis of mitochondrial replacement therapy shows, even with efficient mutant mitochondrial DNA replacement and maintenance in embryonic stem cells, a gradual loss of donor mitochondrial DNA in some lines owing to a polymorphism in the D-loop, potentially causing preferential replication of specific mitochondrial DNA haplotypes. Mitochondrial replacement techniques (MRT) could potentially be used to avoid mother-to-child transmission of...