Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations
Abstract
Analysis of mitochondrial replacement therapy shows, even with efficient mutant mitochondrial DNA replacement and maintenance in embryonic stem cells, a gradual loss of donor mitochondrial DNA in some lines owing to a polymorphism in the D-loop, potentially causing preferential replication of specific mitochondrial DNA haplotypes. Mitochondrial replacement techniques (MRT) could potentially be used to avoid mother-to-child transmission of...
Paper Details
Title
Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations
Published Date
Nov 30, 2016
Journal
Volume
540
Issue
7632
Pages
270 - 275
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Notes
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