Association of resting heart rate and cardiovascular disease mortality in hypertensive and normotensive rural Chinese

Published on May 1, 2017in Journal of Cardiology2.289
· DOI :10.1016/j.jjcc.2016.07.015
Ming Zhang39
Estimated H-index: 39
(SZU: Shenzhen University),
Chengyi Han9
Estimated H-index: 9
(Zhengzhou University)
+ 15 AuthorsDongsheng Hu22
Estimated H-index: 22
(SZU: Shenzhen University)
Abstract Background Studies have demonstrated an increased risk of cardiovascular disease (CVD)-associated death (CVD death) with increased resting heart rate (RHR); however, whether the association is consistent in rural Chinese with hypertension and normotension is unknown. We examined the association of RHR and CVD death by hypertension and normotension status in rural Chinese people. Methods Baseline data for 20,069 participants ≥18 years old were collected during July to August of 2007 and July to August of 2008; 17,151 (85.5%) participants were followed up in July to August of 2013 and July to October of 2014. The association of RHR and CVD death was determined by Cox proportional hazards regression. Results During a mean of 5.88 years (100,889 person-years) of follow-up, we recorded 479 CVD deaths (309 in hypertensive participants). CVD death increased significantly with increasing RHR, beginning from 80 beats per minute (bpm), for hypertensive and normotensive participants. After adjusting for pulse pressure and other covariates, for hypertensive participants, risk of CVD death was increased with RHR 80–89 and ≥90 bpm. However, for normotensive participants, risk of CVD death was increased with only RHR ≥ 90 bpm. Conclusions Risk of CVD death was associated with elevated RHR for both hypertensive and normotensive rural Chinese, and for hypertensive participants, even slightly elevated RHR was associated with CVD death.
  • References (31)
  • Citations (1)
📖 Papers frequently viewed together
9 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
#1Sadaf G. SepanlouH-Index: 50
#2Roger NewsonH-Index: 25
Last. RezaMalekzadehH-Index: 85
view all 16 authors...
BACKGROUND:High blood pressure is the second most important risk factor of cardiovascular diseases (CVDs) in Iran. It is imperative to estimate the burden of CVDs that can be averted if high blood pressure is controlled at the population level. The aim of the current study was to estimate the avertable CVD mortality in the setting of Golestan Cohort Study (GCS). METHODS: Over 50,000 participants were recruited and followed for a median of 7 years. The exposures of interest in this study were non...
7 Citations
#1Yuichiro Yano (NU: Northwestern University)H-Index: 45
#2Jeremiah Stamler (NU: Northwestern University)H-Index: 117
Last. Donald M. Lloyd-Jones (NU: Northwestern University)H-Index: 91
view all 9 authors...
Abstract Background Isolated systolic hypertension (ISH), defined as systolic blood pressure (SBP) ≥140 mm Hg and diastolic blood pressure (DBP) Objective The aim of this study was to assess the risk for cardiovascular disease (CVD) with ISH in younger and middle-aged adults. Methods CVD risks were explored in 15,868 men and 11,213 women 18 to 49 years of age (mean age 34 years) at baseline, 85% non-Hispanic white, free of coronary heart disease (CHD) and antihypertensive therapy, from the Chica...
77 CitationsSource
#1Anxin WangH-Index: 18
#2Xiaoxue LiuH-Index: 9
Last. Shouling WuH-Index: 16
view all 10 authors...
38 CitationsSource
#1Mark Woodward (Johns Hopkins University)H-Index: 115
#2Ruth Webster (The George Institute for Global Health)H-Index: 15
Last. Anthony Rodgers (The George Institute for Global Health)H-Index: 66
view all 10 authors...
Background:Multiple studies have examined the relationship between heart rate and mortality; however, there are discrepancies in results. Our aim was to describe the relationship between resting heart rate (RHR) and both major cardiovascular (CV) outcomes, as well as all-cause mortality in the Asia-Pacific region.Design and methods:Individual data from 112,680 subjects in 12 cohort studies were pooled and analysed using Cox models, stratified by study and sex, and adjusted for age and systolic b...
49 CitationsSource
Fil: Aschner, Pablo. International Diabetes Federation Guideline Development Group; Belgica
566 CitationsSource
Clinical practice guidelines for the management of hypertension in the community a statement by the American society of hypertension and the International society of hypertension
371 CitationsSource
#1Arpit Saxena (USC: University of South Carolina)H-Index: 9
#2Dawn Minton (USC: University of South Carolina)H-Index: 1
Last. Steven N. Blair (USC: University of South Carolina)H-Index: 142
view all 7 authors...
Abstract Objective To study the protective role of lower resting heart rate (RHR) in cardiovascular disease (CVD) and all-cause mortality. Patients and Methods Patients (n=53,322) who received a baseline medical examination between January 1, 1974, and December 31, 2002, were recruited from the Cooper Clinic, Dallas, Texas. They completed a medical questionnaire and underwent clinical evaluation. Patients with CVD or cancer or who had less than 1 year of mortality follow-up were excluded from th...
37 CitationsSource
#1Noël C. BarengoH-Index: 19
#2Riitta AntikainenH-Index: 28
Last. Jaakko TuomilehtoH-Index: 185
view all 5 authors...
The effects of control of systolic and diastolic hypertension on cardiovascular and all-cause mortality in a community-based population cohort
9 CitationsSource
#1Stephen S LimH-Index: 66
#2E. Theo VosH-Index: 107
Last. Majid Ezzati (Imperial College London)H-Index: 107
view all 209 authors...
Methods We estimated deaths and disability-adjusted life years (DALYs; sum of years lived with disability [YLD] and years of life lost [YLL]) attributable to the independent eff ects of 67 risk factors and clusters of risk factors for 21 regions in 1990 and 2010. W e estimated exposure distributions for each year, region, sex, and age group, and relative risks per unit of exposure by systematically reviewing and synthesising published and unpublished data. We used these estimates, together with ...
5,715 CitationsSource
#1Chongjian Wang (Zhengzhou University)H-Index: 10
#2Yuqian Li (Zhengzhou University)H-Index: 7
Last. Ronghai Bie (Zhengzhou University)H-Index: 5
view all 8 authors...
Background Dyslipidemia is an extremely prevalent but preventable risk factor for cardiovascular disease. However, many dyslipidemia patients remain undetected in resource limited settings. The study was performed to develop and evaluate a simple and effective prediction approach without biochemical parameters to identify those at high risk of dyslipidemia in rural adult population. Methods Demographic, dietary and lifestyle, and anthropometric data were collected by a cross-sectional survey fro...
26 CitationsSource
Cited By1
#1Yu-Qing Huang (SCUT: South China University of Technology)H-Index: 5
#2Geng Shen (SCUT: South China University of Technology)
Last. Yingqing Feng (SCUT: South China University of Technology)H-Index: 6
view all 5 authors...
Background: Ischemic stroke is a major public health problem and a main cause of death in China. However, how resting heart rate may associate with ischemic stroke among patients with hyper...
1 CitationsSource
#1Dagfinn Aune (Imperial College London)H-Index: 36
#2Edward Giovannucci (Harvard University)H-Index: 180
Last. Serena Tonstad (Oslo University Hospital)H-Index: 44
view all 10 authors...
Abstract Background and aim Epidemiological studies have reported increased risk of cardiovascular disease, cancer and all-cause mortality with greater resting heart rate, however, the evidence is not consistent. Differences by gender, adjustment for confounding factors, as well as the potential impact of subclinical disease are not clear. A previous meta-analysis missed a large number of studies, and data for atrial fibrillation have not been summarized before. We therefore aimed to clarify the...
181 CitationsSource