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ACUPUNCTURE RESEARCH Acupuncture Treatment Modulates the Resting-State Functional Connectivity of Brain Regions in Migraine Patients without Aura

Published on Jan 1, 2016
Zhang Yong4
Estimated H-index: 4
,
Li Kuang-shi + 3 AuthorsTan Zhong-jian
Abstract
ABSTRACT Objective Objective: To investigate the modulatory effect of acupuncture treatment on the resting-state : To investigate the modulatory effect of acupuncture treatment on the resting-state functional connectivity of brain regions in migraine without aura (MWoA) patients. functional connectivity of brain regions in migraine without aura (MWoA) patients. Methods Methods: Twelve MWoA : Twelve MWoA patients were treated with standard acupuncture treatment for 4 weeks. All MWoA patients received resting-state patients were treated with standard acupuncture treatment for 4 weeks. All MWoA patients received resting-state functional magnetic resonance imaging (fMRI) scanning before and after acupuncture treatment. Another 12 functional magnetic resonance imaging (fMRI) scanning before and after acupuncture treatment. Another 12 normal subjects matched in age and gender were recruited to serve as healthy controls. The changes of resting- normal subjects matched in age and gender were recruited to serve as healthy controls. The changes of resting- state functional connectivity in MWoA patients before and after the acupuncture treatment and those with the state functional connectivity in MWoA patients before and after the acupuncture treatment and those with the healthy controls were compared. healthy controls were compared. Results Results: Before acupuncture treatment, the MWoA patients had signifi cantly : Before acupuncture treatment, the MWoA patients had signifi cantly decreased functional connectivity in certain brain regions within the frontal and temporal lobe when compared decreased functional connectivity in certain brain regions within the frontal and temporal lobe when compared with the healthy controls. After acupuncture treatment, brain regions showing decreased functional connectivity with the healthy controls. After acupuncture treatment, brain regions showing decreased functional connectivity revealed significant reduction in MWoA patients compared with before acupuncture treatment. revealed significant reduction in MWoA patients compared with before acupuncture treatment. Conclusions Conclusions: Acupuncture treatment could increase the functional connectivity of brain regions in the intrinsic decreased brain Acupuncture treatment could increase the functional connectivity of brain regions in the intrinsic decreased brain networks in MWoA patients. The results provided further insights into the interpretation of neural mechanisms of networks in MWoA patients. The results provided further insights into the interpretation of neural mechanisms of acupuncture treatment for migraine. acupuncture treatment for migraine.
  • References (38)
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References38
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#1Lingdi Zhao (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 19
#2Jixin Liu (Xidian University)H-Index: 24
Last. Fanrong Liang (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 26
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Background Acupuncture has been commonly used for preventing migraine attacks and relieving pain during a migraine, although there is limited knowledge on the physiological mechanism behind this method. The objectives of this study were to compare the differences in brain activities evoked by active acupoints and inactive acupoints and to investigate the possible correlation between clinical variables and brain responses.
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#1Shengyuan Yu (Chinese PLA General Hospital)H-Index: 16
#2Mingjie Zhang (Chinese PLA General Hospital)H-Index: 8
Last. Yansheng Li (SJTU: Shanghai Jiao Tong University)H-Index: 1
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Abstract Headache disorders are problematic worldwide. China is no different. A population-based door-to-door survey revealed that the 1-year prevalence of primary headache disorders in China was 23.8%, constituting a major societal burden. Many headache centers and clinics have been established in China, and headache disorders (and associated stress) are receiving an increased level of expert attention. This review summarizes the outcomes of the epidemiological survey and the progress of clinic...
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#1Lingdi Zhao (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 19
#2Wei Qin (Xidian University)H-Index: 35
Last. Fanrong Liang (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 26
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Objective To investigate whether the neural representations underlying alternating two acupoint combinations (ACs) are the same or not.
5 CitationsSource
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#2Antonio Russo (Seconda Università degli Studi di Napoli)H-Index: 16
Last. Gioacchino Tedeschi (Seconda Università degli Studi di Napoli)H-Index: 47
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Background Resting-state functional magnetic resonance imaging (RS-fMRI) has demonstrated disrupted default mode network (DMN) connectivity in a number of pain conditions, including migraine. However, the significance of altered resting-state brain functional connectivity in migraine is still unknown. The present study is aimed to explore DMN functional connectivity in patients with migraine without aura (MwoA) and investigate its clinical significance.
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#2Jaung-gengLIN (PRC: China Medical University (PRC))H-Index: 27
Last. Wei-Zen Sun (NTU: National Taiwan University)H-Index: 30
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ABSTRACT We review the literature conjoining acupuncture, migraine, and cerebral hemodynamics. To do so, we searched PubMed in March 2013 for studies investigating cerebral hemodynamics with functional magnetic resonance imaging (fMRI), near-infrared spectroscopy (NIRS), transcranial Doppler (TCD) ultrasound, and other tools in migraineurs, acupuncture recipients, and migraineurs receiving acupuncture. Our search identified 1321 distinct articles – acupuncture ( n = 463), migraine ( n = 866), an...
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#1Francesco PierelliH-Index: 39
#2Elisa Iacovelli (Sapienza University of Rome)H-Index: 17
Last. Gianluca CoppolaH-Index: 28
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Abstract The period between migraine attacks is characterized by paradoxical responses to repetitive sensory and transcranial magnetic stimulation (TMS). Abnormal long-term cortical functional plasticity may play a role and can be assessed experimentally by paired associative stimulation (PAS), in which somatosensory peripheral nerve stimuli are followed by TMS of the motor cortex. Changes in motor-evoked potential (MEP) amplitudes were recorded in 16 migraine without aura patients (MO) and 15 h...
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Acupuncture is currently gaining popularity as an important modality of alternative and complementary medicine in the western world. Modern neuroimaging techniques such as functional magnetic resonance imaging, positron emission tomography, and magnetoencephalography open a window into the neurobiological foundations of acupuncture. In this review, we have summarized evidence derived from neuroimaging studies and tried to elucidate both neurophysiological correlates and key experimental factors ...
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#1Faisal Mohammad Amin (UCPH: University of Copenhagen)H-Index: 16
#2Mohammad Sohail Asghar (UCPH: University of Copenhagen)H-Index: 12
Last. Messoud Ashina (UCPH: University of Copenhagen)H-Index: 44
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Summary Background Extracranial arterial dilatation has been hypothesised to be the cause of pain in patients who have migraine without aura. To test that hypothesis, we aimed to measure extracranial and intracranial arteries during attacks of migraine without aura. Methods In this cross-sectional study, we recruited patients aged 18–60 years from the Danish Headache Centre and via announcements on a Danish website. We did magnetic resonance angiography during spontaneous unilateral migraine att...
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#1Dawn C. Buse (Albert Einstein College of Medicine)H-Index: 36
#2Richard B. Lipton (Albert Einstein College of Medicine)H-Index: 97
Recent studies have profiled chronic migraine (CM) and episodic migraine (EM) in many regions of the world using samples derived from various sources. In a previous issue of Cephalalgia, Wang and colleagues contrast patients with CM and EM recruited from two headache clinics in Taiwan (1). Their results add to the growing evidence indicating that, in comparison with EM, CM is less common but far more burdensome to individuals, as evidenced by measures of headacherelated disability, medical and p...
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The experience of pain can be significantly influenced by expectancy (predictive cues). This ability to modulate pain has the potential to affect therapeutic analgesia substantially and constitutes a foundation for non-pharmacological pain relief. In this study, we investigated 1) brain regions involved in visual cue modulation of pain during anticipation of pain, pain administration, and pain rating; and 2) the association between pre-test resting-state functional connectivity and the magnitude...
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