Andrographolide impedes cancer stemness and enhances radio-sensitivity in oral carcinomas via miR-218 activation
Abstract
Current evidence suggests that oral cancer stem cells (OCSCs) possess high tumorigenic and metastatic properties as well as chemo- and radioresistance. In this study, we demonstrated that andrographolide, the main bioactive component in the medicinal plant Andrographis, significantly reduced oncogenicity and restored radio-sensitivity of ALDH1+CD44+ OCSCs. Mechanistic studies showed that andrographolide treatment increased the expression of...
Paper Details
Title
Andrographolide impedes cancer stemness and enhances radio-sensitivity in oral carcinomas via miR-218 activation
Published Date
Dec 1, 2016
Journal
Volume
8
Issue
3
Pages
4196 - 4207
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