Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity
Abstract
Type 1 diabetes is characterized by the destruction of pancreatic β cells, and generating new insulin-producing cells from other cell types is a major aim of regenerative medicine. One promising approach is transdifferentiation of developmentally related pancreatic cell types, including glucagon-producing α cells. In a genetic model, loss of the master regulatory transcription factor Arx is sufficient to induce the conversion of α cells to...
Paper Details
Title
Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity
Published Date
Jan 1, 2017
Journal
Volume
168
Issue
1-2
Pages
86 - 100.e15
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Notes
History