Structural Basis for Interaction Between NO66 and Osterix

The differentiation of mesenchymal stem cells to osteoblasts is one of the critical steps of bone formation. Osterix (Osx) is an osteoblast-specific transcriptional factor required for bone formation and osteoblast differentiation, which has been shown to interact with other factors to control the expression of osteoblast-specific genes. A novel JmjC domain containing protein NO66 has been identified in the regulation network of Osx, which plays...