Guidance for the utility of linear models in meta-analysis of genetic association studies of binary phenotypes
Abstract
Linear mixed models are increasingly used for the analysis of genome-wide association studies (GWAS) of binary phenotypes because they can efficiently and robustly account for population stratification and relatedness through inclusion of random effects for a genetic relationship matrix. However, the utility of linear (mixed) models in the context of meta-analysis of GWAS of binary phenotypes has not been previously explored. In this...
Paper Details
Title
Guidance for the utility of linear models in meta-analysis of genetic association studies of binary phenotypes
Published Date
Nov 16, 2016
Volume
25
Issue
2
Pages
240 - 245
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