RANKL/RANK: from bone loss to the prevention of breast cancer
Abstract
RANK and RANKL, a receptor ligand pair belonging to the tumour necrosis factor family, are the critical regulators of osteoclast development and bone metabolism. Besides their essential function in bone, RANK and RANKL have also been identified as the key factors for the formation of a lactating mammary gland in pregnancy. Mechanistically, RANK and RANKL link the sex hormone progesterone with stem cell expansion and proliferation of mammary...
Paper Details
Title
RANKL/RANK: from bone loss to the prevention of breast cancer
Published Date
Nov 1, 2016
Journal
Volume
6
Issue
11
Pages
160230 - 160230
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Notes
History