Cdc24 Is Essential for Long-range End Resection in the Repair of Double-stranded DNA Breaks

Double-stranded DNA breaks (DSBs) are highly detrimental DNA lesions, which may be repaired by the homologous recombination-mediated repair pathway. The 5′ to 3′ direction of long-range end resection on one DNA strand, in which 3′-single-stranded DNA overhangs are created from broken DNA ends, is an essential step in this pathway. Dna2 has been demonstrated as an essential nuclease in this event, but the molecular mechanism of how Dna2 is...