Interplay of cis- and trans-regulatory mechanisms in the spliceosomal RNA helicase Brr2.

Volume: 16, Issue: 1, Pages: 100 - 112
Published: Jan 2, 2017
Abstract
RNA helicase Brr2 is implicated in multiple phases of pre-mRNA splicing and thus requires tight regulation. Brr2 can be auto-inhibited via a large N-terminal region folding back onto its helicase core and auto-activated by a catalytically inactive C-terminal helicase cassette. Furthermore, it can be regulated in trans by the Jab1 domain of the Prp8 protein, which can inhibit Brr2 by intermittently inserting a C-terminal tail in the enzyme's...
Paper Details
Title
Interplay of cis- and trans-regulatory mechanisms in the spliceosomal RNA helicase Brr2.
Published Date
Jan 2, 2017
Journal
Volume
16
Issue
1
Pages
100 - 112
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