DNA Damage Response and Autophagy: A Meaningful Partnership
Abstract
Autophagy and the DNA damage response (DDR) are biological processes essential for cellular and organismal homeostasis. Herein, we summarize and discuss emerging evidence linking DDR to autophagy. We highlight published data suggesting that autophagy is activated by DNA damage and is required for several functional outcomes of DDR signaling, including repair of DNA lesions, senescence, cell death, and cytokine secretion. Uncovering the...
Paper Details
Title
DNA Damage Response and Autophagy: A Meaningful Partnership
Published Date
Nov 21, 2016
Journal
Volume
7
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