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Cancer Incidence in Asbestos-Exposed Workers: An Update on Four Finnish Cohorts

Published on Jun 1, 2017in Safety and health at work1.431
· DOI :10.1016/j.shaw.2016.11.003
Pia Nynäs1
Estimated H-index: 1
(Finnish Institute of Occupational Health),
Eero Pukkala92
Estimated H-index: 92
(RMIT: RMIT University)
+ 1 AuthorsPanu Oksa1
Estimated H-index: 1
(RMIT: RMIT University)
Abstract
Abstract Background We assessed the cancer risks of four different Finnish asbestos-exposed cohorts. We also explored if the cohorts with varying profiles of asbestos exposure exhibited varying relative risks of cancer. Methods The incident cancer cases for the asbestos-exposed worker cohorts were updated to the end of 2012 using the files of the Finnish Cancer Registry. The previously formed cohorts consisted of asbestos mine workers, asbestosis patients, asbestos sprayers, and workers who had taken part in a screening study based on asbestos exposure at work. Results The standardized incidence ratio (SIR) for mesothelioma varied from about threefold to > 100-fold in the different cohorts. In the screening cohort the SIR for mesothelioma was highest in 2003–2007, In other cohorts it was more constant in 5-year period inspection. The SIR for lung cancer was about twofold to tenfold in all except the screening cohort. Asbestos sprayers were at the highest risk of mesothelioma and lung cancer. Conclusion The SIR for mesothelioma is high in all of the cohorts that represent different kinds of asbestos exposure. The smaller SIR for mesothelioma in the screening cohort with lowest level of asbestos exposure might suggest dose-responsiveness between asbestos exposure and mesothelioma. It does seem that the highest risk of lung cancer in these cohorts except in the youngest of the cohorts, the screening cohort, is over. The highest SIR for lung cancer of the asbestosis patient and sprayers cohort is explained by their heavy asbestos exposure.
  • References (12)
  • Citations (6)
References12
Newest
#1Henrik Wolff (Finnish Institute of Occupational Health)H-Index: 31
#2Tapio Vehmas (Finnish Institute of Occupational Health)H-Index: 30
Last. Harri Vainio (Finnish Institute of Occupational Health)H-Index: 61
view all 5 authors...
IntroductionAlthough the use of asbestos has been banned in several industrialized countries, many workers continue to be exposed in asbestos repair and removal work, and asbestos is still widely used in various newly industrialized, rapidly developing countries. According to the most recent World Health Organization (WHO) estimates, more than 107 000 people die each year from asbestos-related lung cancer, mesothelioma, and asbestosis resulting from exposure at work (1). The asbestos epidemic is...
80 CitationsSource
#1Aude Lacourt (French Institute of Health and Medical Research)H-Index: 10
#2Celine Gramond (French Institute of Health and Medical Research)H-Index: 3
Last. Patrick Brochard (French Institute of Health and Medical Research)H-Index: 35
view all 15 authors...
Objectives To estimate the proportion of pleural mesothelioma cases that can be attributed to asbestos exposure in France including non-occupational exposure. Methods A population-based case-control study including 437 incident cases and 874 controls was conducted from 1998 to 2002. Occupational and non-occupational asbestos exposure was assessed retrospectively by two expert hygienists. ORs of pleural mesothelioma for asbestos-exposed subjects compared to non-exposed subjects, and population-at...
48 CitationsSource
#1Bengt Järvholm (Umeå University)H-Index: 45
#2h.c. Anders Englund Md (Umeå University)H-Index: 1
OBJECTIVE: To study the occurrence of pleural mesothelioma as a measure of the impact on health from asbestos exposure in the construction industry.METHODS: The occurrence of pleural mesothelioma i ...
10 CitationsSource
#1Panu OksaH-Index: 18
#2Lea PaloH-Index: 2
Last. Simo VirtanenH-Index: 8
view all 7 authors...
3 Citations
#1Kurt Straif (IARC: International Agency for Research on Cancer)H-Index: 63
#2Lamia Benbrahim-Tallaa (IARC: International Agency for Research on Cancer)H-Index: 27
Last. Vincent Cogliano (IARC: International Agency for Research on Cancer)H-Index: 33
view all 11 authors...
503 CitationsSource
Objectives Cancer risk has been estimated for asbestos production workers or other heavily exposed asbestos workers in numerous studies. The bulk of the asbestos epidemic results come, however, from past intermittent exposures during asbestos product use. This study concentrated on estimating the risk of cancer in such a population. Methods Altogether 23 285 men and 930 women invited to a nationwide screening campaign for benign asbestos-related diseases in 1990-1992 were followed for cancer thr...
10 CitationsSource
#1Panu OksaH-Index: 18
#2Eero PukkalaH-Index: 92
Last. Matti S. Huuskonen (Finnish Institute of Occupational Health)H-Index: 19
view all 5 authors...
Cohorts of Finnish asbestos sprayers and of asbestosis and silicosis patients were followed for cancer with the aid of the Finnish Cancer Registry in the period 1967–1994. Compared with the cancer incidence of the total Finnish population, asbestos sprayers had an increased risk for total cancer (standardized incidence ratio [SIR] 6.7, 95% confidence interval [95% CI] 4.2–10); lung cancer (SIR 17, 95% CI 8.2–31); and mesothelioma (SIR 263, 95% CI 85–614). The SIR of the asbestosis patients was 3...
33 CitationsSource
#1Matti S. Huuskonen (Finnish Institute of Occupational Health)H-Index: 19
#2Kari Koskinen (Finnish Institute of Occupational Health)H-Index: 8
Last. Jorma Rantanen (Finnish Institute of Occupational Health)H-Index: 15
view all 6 authors...
In 1987–1992, the Finnish Institute of Occupational Health (FIOH) implemented a nationwide asbestos program aimed at preventing asbestos-related risks in good cooperation with governmental authorities, industry, trade unions, the health care and insurance systems, and mass media. The goals were to minimize all exposure to asbestos, identify people exposed at work, and improve the diagnostics of asbestos diseases, especially cancers. The program entailed several concrete actions and extensive dis...
29 CitationsSource
#1L O MeurmanH-Index: 1
#2E PukkalaH-Index: 1
Last. Matti HakamaH-Index: 65
view all 3 authors...
A cohort of 736 male and 167 female workers of two anthophyllite mines in Finland was followed up through the Finnish Cancer Registry for cancer in 1953-91. Compared with the total cancer incidence of the east Finnish population, the men had a raised risk of total cancer (standardised incidence ratio (SIR) 1.7; 95% confidence interval (95% CI) 1.4-1.9), mainly attributable to an excess in lung cancer (SIR 2.8; 95% CI 2.2-3.6). The risk of lung cancer was somewhat higher among workers classified ...
56 CitationsSource
#1A KarjalainenH-Index: 1
#2L O MeurmanH-Index: 1
Last. E PukkalaH-Index: 1
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Four cases of mesothelioma in a cohort of 999 Finnish anthophyllite miners and millers are described. Three deaths were due to pleural mesothelioma and one to peritoneal mesothelioma among the total of 503 male deaths up to 1991. All four patients with mesothelioma had had long term (13 to 31 years) exposure in anthophyllite mining and milling. The latency time from the onset of employment until diagnosis was 39 to 58 years. All four patients were smokers or ex-smokers and had asbestosis. In thr...
33 CitationsSource
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Abstract In the second half of the 20th century, asbestos extraction was up to 4 Mt/year. Due to its high strength and insulation properties, this mineral was used as an additive in building materials. Over time these materials were destroyed by the process of weathering and leaching. Asbestos fibers in dust form penetrate the respiratory system causing diseases. This article proposes the binding of hazardous asbestos fibers in a polymer matrix formed from waste cooking oil. Compact materials we...
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#1Paolo Boffetta (UNIBO: University of Bologna)H-Index: 130
#2Francesca de’Donato (UNITO: University of Turin)H-Index: 14
Mesothelioma is a relatively rare but very severe neoplasm that affects primarily the pleura and the peritoneum, and very rarely also the pericardium, the tunica vaginalis of the testis and the ovary. An increased risk of mesothelioma has been demonstrated in many occupational groups exposed to asbestos, with higher risk for exposure to amphiboles such as crocidolite and amosite than to chrysotile.
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#1Yaghoub Hajizadeh (IUMS: Isfahan University of Medical Sciences)H-Index: 10
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Abstract Asbestos is classified as a hazardous pollutants between the airborne particles that cause diseases such as lung fibrosis (asbestosis). This protocol describes an integrated method for determination of asbestos fibres concentration and its temporal-spatial trends in the air of urban areas. To do this, 60 samples were gathered from various areas of Yazd city with low, moderate and high traffic. For analysis of asbestos fibres in the samples scanning electron microscopy (SEM) and energy-d...
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#1Emmanouil Velonakis (UoA: National and Kapodistrian University of Athens)H-Index: 1
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Exposure to asbestos remains a global issue due to its massive use in the twentieth century and its long environmental persistence. Exposure to asbestos still occurs during dismantling of ships and vessels, buildings renovation, mining operations, and is reported in developing countries. Current estimate report exposure of hundreds of million people in occupational settings in countries where its use remains unregulated. We conducted a historical prospective cohort mortality study aimed at estim...
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#1Sunwook Park (Kosin University)H-Index: 1
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The International Agency for Research on Cancer (IARC) defined that asbestos is a group 1 substance that causes lung cancer, mesothelioma (pleura and peritoneum), laryngeal cancer, and ovarian cancer in humans. Many studies on lung cancer, and mesothelioma caused by asbestos exposure have been conducted, but there was no case report of ovarian cancer due to asbestos exposure in Korea. We describe a case of ovarian cancer caused by asbestos exposure in a worker who worked at an asbestos textile f...
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#1Haruna Musa Moda (MMU: Manchester Metropolitan University)H-Index: 1
#2Henry Olawale Sawyerr (Kwara State University)H-Index: 2
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AbstractAsbestos is a naturally occurring silicate with six varieties from two groups of minerals serpentine (chrysotile) and five amphiboles (amosite, crocidolite, tremolite, anthrophyllite and actinolite) with chrysotile widely used form. Asbestos-containing materials (ACM) use in Nigeria from 1970 to 2000 was 1,091,370 tons. Its demand peak coincided with landmark edifices construction in the country that include FESTAC Village and the National Theatre Iganmu. The inward low-cost housing cons...
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Anthophyllite asbestos only occurs in a few parts of the world in sufficient quantities to be mined. The largest deposits of anthophyllite asbestos occur in Finland where it was mined for more than 75 years and very extensively used and distributed, anciently, for more than six millennia. Anthophyllite is one of the five minerals known collectively as amphibole asbestos. Studies of the effect of these five mineral fibre types when inhaled have shown that fibre width is an important determinant o...
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